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There are interactions between cannabis and opioids, and Tramadol is a synthetic opioid. The clinical significance of these interactions is dose-dependent, and  A Major Drug Interaction exists between cannabis and tramadol. View detailed information regarding this drug interaction. An interaction with CBD can cause elevated levels of another drug the person Is there any interaction with low dose ambien, klonopin, tramadol, gabapentin,  28 Feb 2019 Here's what we know so far about using CBD while you're taking psych of CBD in a day should be prepared for an interaction of some kind,  16 Aug 2019 Tramadol is a unique prescription pain medicine similar to opioids. From minor side effects to life-threatening allergic reactions, every decision to take a CBD seems to help ease it some, btw, in case others read this.